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Image Search Results
Journal: Hematology, transfusion and cell therapy
Article Title: NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma.
doi: 10.1016/j.htct.2024.02.017
Figure Lengend Snippet: Figure 4 – NT157 favors a tumor-suppressive molecular profile in multiple myeloma cells. (A) Western blot analysis phospho (p)-IGF1R, IGF1R, IRS1, IRS2, p-STAT3, STAT3, p-STAT5, STAT5, p-RPS6, RPS6, p-ERK1/2, ERK1/2, PARP1 (total and cleaved), and gH2AX in the total extract from MM.1S and MM.1R cells treated with vehicle or NT157 (6.4 mM) for 24 h. The membranes were re-probed for the detection of a-tubulin and developed using a SuperSignalTM West Dura Extended Duration Substrate system
Article Snippet: Antibodies against phospho(p)-IGF1RTyr1135 (#3918), IGF1R (#3027), IRS1 (#3407), IRS2 (#3089), p-STAT3Tyr705, (#9131) STAT3 (#4905), p-STAT5Tyr694 (#9359),
Techniques: Western Blot